Risk Assessment for Thromboembolic Events in Pediatric Inflammatory Bowel Disease

Thrombotic events in adult patients with inflammatory bowel disease (IBD) are associated with numerous combinations of genetic and acquired risk factors. There was a scarcity of published data on children with IBD. For a study, researchers sought to determine the thromboembolic risk factors in children with IBD. They recruited three groups of children: one with Crohn’s disease (cD), another with ulcerative colitis (Uc), and a healthy control group. The possible thromboembolic risk was examined clinically and by laboratory testing for all individuals.

They evaluated 30 CD children (25.6%), 28 UC children (23.9%), and 59 (50.4%) healthy control participants. There were no significant differences between thromboembolic risk variables and disease activity as measured by the Pediatric Crohn Disease Activity Index. Instead, there was a statistically significant difference in serum fibrinogen levels between kids with mild and moderate/severe UC, as measured by the Pediatric Ulcerative Colitis Activity Index [3.8 (3.2–4.5) g/L vs. 5.7 (4.8–6.2) g/L, P<0.0032]. Healthy controls had lower blood homocysteine levels than CD (P=0.176) and UC (P=0.026) patients. A homozygous mutation in the methylene tetrahydrofolate reductase C677T gene resulted in a rise in homocysteine levels in UC. The research found that, like adults, children with IBD had clinical characteristics and acquired and congenital variables that might raise the thrombotic risk.


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